Ako smatrate da je učinak Apaurina prejak ili preslab, porazgovarajte sa svojim ljekarom ili farmaceutom.
Itrakonazol, ketokonazol i u manjoj meri flukonazol i vorikonazol su snažni inhibitori izoenzima CYP3A4 citohroma P450 i mogu povećati koncentraciju benzodiazepina u plazmi.
Normally, the use of diazepam in Women of all ages of childbearing opportunity, plus more particularly throughout recognized pregnancy, ought to be thought of only in the event the scientific condition warrants the chance on the fetus . The possibility that a girl of childbearing probable could possibly be Expecting at the time of establishment of therapy needs to be regarded as .
Lijek Apaurin se ne smije upotrijebiti nakon isteka roka upotrebe navedenog na pakovanju. Datum isteka roka upotrebe odnosi se na zadnji dan navedenog mjeseca.
Starije osobe mogu trebati niže doze Apaurina od mlađih bolesnika. Ako ste stariji, ljekar Vam može propisati nižu dozu i provjeriti Vaš odgovor na liječenje. Molimo Vas da pažljivo slijedite uputstva Vašeg ljekara.
Utilize the medication as prescribed by your health practitioner. The knowledge provided just isn't meant to deal with all achievable uses. This facts is generalized and not supposed as precise healthcare suggestions. When you have questions on using your prescription, please Speak to your prescriber.
As an anxiolytic, the lowest successful dose really should be used; dosage regimes shouldn't exceed further than 14 days. People who definitely have been given benzodiazepines for some time may possibly involve an prolonged withdrawal time period. Extensive-term chronic use will not be encouraged.
. Watch out and make sure you specify the information on the part within the Recommendations to the drug Apaurin directly from the package deal or from your pharmacist with the pharmacy. additional...
Fenitoin je poznati induktor CYP3A4 APAURIN KRKA i ubrzava metabolizam diazepama u jetri. Smanjeno dejstvo diazepama. Diazepam deluje na metabolizam fenitoina na nepredvidiv način: metabolizam fenitoina pod dejstvom diazepama može biti ubrzan ili usporen, ili ostati nepromenjen.
Nije preporučljivo uzimanje Apaurina tokom trudnoće i daje se jedino u nužnim situacijama kada očekivana korist za majku opravdava rizik za plod. Pošto se lek izlučuje mlekom, ne daje se dojiljama ili se dojenje mora prekinuti.
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Diazepam can have an affect on other Diseases (for example glaucoma, liver disease, respiratory disorder), so you should examine other health care troubles using your medical doctor before starting diazepam suppositories. Utilize the medication as prescribed by your health care provider. The knowledge offered isn't meant to deal with all doable employs. This details is generalized instead of intended as unique health care advice. If you have questions about using your prescription, make sure you Make contact with your prescriber.
Poznato je da istovremena primena diazepama i kombinovanih oralnih kontraceptiva može dovesti do probojnog krvarenja. Mehanizam ove reakcije nije poznat. Nisu prijavljeni slučajevi neuspele kontracepcije.
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